郭雷，男，博士，副教授，连云港市“521工程“第三层次培养对象，主要从事抗菌活性物质和食品功能因子的研究。
一、教学情况
生物制药工艺学（本科）、生物制品及药品检验（本科）、生物分离工程（研究生）、海洋生物活性物质制备工程技术（研究生）、生命科学导论（公选）
二、科研情况
· 发表论文
1. Wang Cong†,Guo Lei†, Hao Jiejie, Wang Liping, Zhu Weiming*. α‑Glucosidase inhibitors from the marine-derived fungus Aspergillus flavipes HN4-13.J Nat Prod, 2016, 79:2977-2981. (†Co-first author)
2.Guo Lei*, Wang Cong, Zhu Wencheng, Xu Fuquan. Bioassay-guided fractionation and identification of active substances from the fungusAspergillus tubingensisagainstVibrio anguillarum.Biotechnol Biotec Eq, 2016, 30(3): 602-606.
3.Guo Lei*, Guo Jiacai,Zhu Wencheng, Jiang Xinru. Optimized synchronous extraction process of tea polyphenols and polysaccharides from Huaguoshan Yunwu tea and their antioxidant activities.Food Bioprod Process, 2016, 100:303-310.
4. Zhao Chengying†,Guo Lei†, Wang Liping, Zhu Guoliang, Zhu Weiming*. Improving the yield of (+)-terrein from the salt-tolerantAspergillus terreusPT06-2.World J Microb Biot, 2016, 32:77. (†Co-first author)
5.Guo Lei*, Huang Tao, Hu Bing, Wang Cong. Bioactivity-guided isolation and characterization of antitumor active compound from marine-derived fungusPenicillium chrysogenumHGQ6.Adv J Food Sci Technol, 2016, 10(5):353-355.
6.Guo Lei*, Zhu Wencheng, Xu Fuquan, Liu Ming, Xie Yu, Zhang Jingmin.Optimized ultrasonic-assisted extraction of polysaccharides fromCyclina sinensisand evaluation of antioxidant activities in vitro,CyTA J Food, 2014, 12(1): 32-39.
7.Guo Lei*, Zhu Wencheng, Zheng Anqi. Identification and fermentation optimization of an antibacterialAspergillus tubingensisassociated with the crabPortunus triuberbuculatus,J Pure Appl Microbio,2014, 8(2): 1627-1633.
8.Guo Lei*, Liu Yanli, Liu Chao.Evaluation of Antioxidative Properties of Various Extracts from Cyclina sinensis,Adv J Food Sci Technol,2014, 6(4): 558-562.
9. Sun KL, Li Y,Guo Lei, Wang Y, Liu PP, Zhu WM*.Indole Diterpenoids and Isocoumarin from the Fungus,Aspergillus flavus, Isolated from the Prawn,Penaeus vannamei,Mar Drugs,2014, 12(7): 3970-3981.
10.Guo Lei*, Zhu Wencheng, Liu Yating, Wu Jiuyu, Zheng Anqi, Liu Yanli.Response surfaceoptimized extraction of flavonoids from Mimenghua and its antioxidant activities in vitro,Food Sci Biotechnol,2013, 22(5): 1285-1292.
11.Guo Lei*, Zhu Wencheng, Liu Chao.Fermentation conditions optimization of anti-tumor active metabolites from marinePenicilliumsp. HGQ6,Adv Mater Res, 2012, 340:344-350.
12.Guo Lei*，Gong Bangqiang.Isolation and identification of mPGES-1 expression inhibitor fromCraibiodendron yunnanense,Nat Prod Res Deve, 2008, 20(5): 839-841.
13.Guo Lei, Hu Weirong, Lian Jihong, Ji Wei, Deng Ting, Qian Ming, Gong Bangqiang*. Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivo,Eur J Pharmacol, 2006, 551(1-3): 80-86.
14.Guo Lei, Lian Jihong, Ji Wei, Hu Weirong, Wu Guolong, Gong Bangqiang*.Establishment of a cell-based drug screening system for identifying selective down-regulators of mPGES-1,Inflamm Res, 2006, 55(3): 114-118.
15.郭雷*,朱文成,刘玮炜,丁国伟,张越乾,张守禄,邱月,谢宇.抗菌活性海洋真菌HN4-13的鉴定及其发酵优化，微生物学通报, 2013, 40(6): 951-958.
· 承担科研项目
1. 连云港市科技项目（产业前瞻与共性关键技术），CG1612，海水养殖虾蟹育苗期弧菌病防治生物制剂开发的关键技术研究，2016/11-2018/10
2. 连云港市第五期“521工程”科研项目，海洋黄柄曲霉源大黄素-8-甲醚抗哈维氏弧菌的效应与作用机制研究，2016/12-2018/12
3. 江苏省自然科学基金面上项目，海洋黄柄曲霉源大黄素-8-甲醚抗水产病原哈氏弧菌的效应及作用机理研究，2015/07-2018/06
4. 江苏省“海洋科学与技术”优势学科专项资金科研创新项目，海洋真菌水用抑菌活性化合物的发掘，2015/05-2017/06，3万元，在研，主持
5. 海洋动物源真菌A. tubingenesisSZX-6菌株抗水产病原菌活性物质研究，江苏省海洋生物技术重点实验室开放基金，2014.12-2016.12
6. 海洋黄柄曲霉HN4-13菌株抗水产病原菌活性次生代谢产物研究，国家海洋局海洋生物活性物质与分析技术重点实验室开放基金，2013.07-2015.06
7. 海洋真菌Aspergillus flavipesHN4-13抗肿瘤抗菌活性次生代谢产物的研究，教育部海洋药物重点实验室开放基金，2013.01-2014.12
8. 海洋微生物抗水产病原菌活性次级代谢产物及其生防制剂的研制，连云港市农业科技攻关项目，2011.11-2013.12
· 成果获奖情况
1. 连云港市第五期“521”工程第三层次培养对象
2. 2013年江苏省优秀毕业设计（论文）三等奖指导教师
· 专利情况
1.郭雷,王聪,许福泉.利用海洋黄柄曲霉HN4-13菌株制备大黄素-8-甲醚的方法与用途
2.郭雷,朱文成,许福泉,刘玮炜,陈丽.塔宾曲霉SZX-6及其发酵液和发酵液提取物与用途
3.郭雷,王淑军,陆新龙,陆博.一种樱桃果酒的酿造方法
